• Streptavidin-FITC in Quantitative Endosomal Trafficking a...

  2025-09-22

  This article explores the advanced use of Streptavidin-FITC as a quantitative probe for studying endosomal trafficking and biotinylated molecule detection, highlighting recent methodological innovations and interpreting new data on lipid nanoparticle intracellular dynamics. Streptavidin-FITC's high biotin affinity and robust fluorescence enable precise tracking in complex cellular environments.

• Eltanexor (KPT-8602): Expanding Frontiers in Nuclear Expo...

  2025-09-19

  Eltanexor (KPT-8602), a second-generation XPO1 inhibitor, is redefining cancer research by targeting nuclear export pathways implicated in hematological malignancies and solid tumors. This article examines Eltanexor's mechanistic profile, recent findings on Wnt/β-catenin modulation, and its expanding role in preclinical cancer therapeutics.

• VX-765: A Selective Caspase-1 Inhibitor for Inflammation ...

  2025-09-18

  Explore the scientific utility of VX-765, a potent caspase-1 inhibitor, in dissecting inflammatory signaling, pyroptosis inhibition in macrophages, and cell death pathways. This article provides new perspectives on VX-765’s role in illuminating the interplay between caspase signaling and transcriptional regulation mechanisms.

• br Disclosure br Acknowledgments br Introduction Anaplastic

  2025-03-03

  

  Disclosure Acknowledgments Introduction Anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase, belongs to the insulin receptor kinase subfamily [1]. Oncogenic activation of ALK is associated with the Drug Repurposing Library and progression of multiple human cancer types [2,3], inclu

• In summary the different types of interstitial

  2025-03-03

  

  In summary, the different types of interstitial cells found in the current study are illustrated in Fig. 7A (see legend for further details), which is suggestive of a heterogeneous complex network of interstitial cells communicating with each other. The possible signaling pathways involving this int

• Here we have used transcriptome analysis of primary neonatal

  2025-03-03

  

  Here, we have used transcriptome analysis of primary neonatal rat cardiomyocytes treated with either the ETR agonist endothelin-1 or the α1-AR agonist phenylephrine to assess differences in their respective signalling networks, and further probed these differences using a panel of fluorescent resona

• PKA signalling in the http www apexbt com media

  2025-03-03

  

  PKA signalling in the nucleus was thought to be due to the translocation of the catalytic subunit upon activation from the EdU detection kit HF594 to the nucleus via diffusion [72]. However, a new understanding has emerged, as both the regulatory and catalytic subunits have been identified in the n

• br Endoplasmic reticulum protein ERp binds to AdipoR in HeLa

  2025-03-03

  

  Endoplasmic reticulum protein 46 (ERp46) binds to AdipoR1 in HeLa cells ERp46 is localized in the ER and is suggested to act as a chaperone. About 20% of endogenous ERp46 are found at the plasma membrane suggesting that this protein may have additional functions. ERp46 interacts with hcv virus 1

• Beside activation of adenosine receptors A a A a A

  2025-03-03

  

  Beside activation of adenosine receptors (A2a.1, A2a.2, A2b) by FSK treatment, the expression of adenosine receptors was also upregulated, when embryos were exposed to inhibitors (SU5416 and DAPT) alone and also combined with FSK. Our data imply that adenosine receptor was associated with a positive

• br Experimental procedure br Introduction Migraine

  2025-03-03

  

  Experimental procedure Introduction Migraine is a debilitating neurovascular disorder characterized by recurring unilateral pulsating headaches of moderate to severe intensity, associated with nausea, photophobia and/or phonophobia, lasting from 4 to 72 h (Headache Classification Committee of

• Cancer cells manifest characteristic abnormal growth propert

  2025-03-03

  

  Cancer PLX7904 synthesis manifest characteristic abnormal growth properties accompanying clonal evolution of cells displaying progressively increasing genomic instability capable of invasion and metastasis to distant organ sites. With the emerging knowledge about the role of known oncogene and tumo

• The tumor suppressor function of LOX

  2025-03-01

  

  The tumor-suppressor function of 15-LOX-2 in normal prostate epithelial cells may be explained by the induction of replicative senescence [14,15]. Thus, 15-LOX-2 is overexpressed in age-dependent prostatic hyperplasia, but cell senescence may hinder progression to malignant transformation. Notwithst

• Atherosclerosis is a chronic lipid metabolism disorder linke

  2025-03-01

  

  Atherosclerosis is a chronic lipid metabolism disorder linked with lipid accumulation within the arterial wall and subsequent formation of foam cells and vascular disease [96], [97]. The level of apelin is decreased in human atherosclerotic coronary arteries [4], and coronary collateral formation in

• br Conclusion br Competing interests br Funding The Bolger

  2025-03-01

  

  Conclusion Competing interests Funding The Bolger Prostate Cancer Research Fund (no grant number), the National Institute of General Medical Sciences of the National Institutes of Health (1-R01-GM58553, G. B. Bolger, principal investigator), and the National Cancer Institute of the NIH to t

• Glycosylphosphatidylinositol GPI cell wall anchor

  2025-03-01

  

  Glycosylphosphatidylinositol (GPI) ptc124 anchor synthesis pathway is another promising antifungal target. Novel inhibitors of Gwt1 and Mcd4, two enzymes in the GPI anchor pathway were identified by the chemical-genomics-based screening platform CaFT (Candida albicans fitness test) [89]. Screening

15889 records 1/1060 page Next 12345 下5页 Last page