• br Acknowledgements This work was supported by grants

  2019-07-15

  

  Acknowledgements This work was supported by grants from Agence Nationale de la Recherche (ANR CAPHE) and from Ligue contre le Cancer. We acknowledge the continuous support of CNRS and the University of Strasbourg. We thank the technical assistance of the “Plateforme de Chimie Intégrative de Stras

• The purposes of this study

  2019-07-15

  

  The purposes of this study is to develop an experimental model of CysLT2 receptor-mediated LTC4-induced lung air-trapping in guinea pigs using S-hexyl GSH, and to clarify the mechanism underlying response to such trapping using montelukast, a CysLT1 receptor antagonist, BayCysLT2RA, a CysLT2 recepto

• Immunofluorescence Cells were fixed with paraformaldehyde PF

  2019-07-15

  

  Immunofluorescence. Cells were fixed with 4% paraformaldehyde (PFA) in PBS and extracted by 0.5% Triton X-100-PBS, or fixed in cold methanol. The cells were immunostained with mouse monoclonal hyPerFUsion™ high-fidelity DNA polymerase against α-tubulin (Sigma), γ-tubulin (Sigma), Ran (Upstate), rab

• Taken together our results demonstrate that the changes

  2019-07-15

  

  Taken together, our results demonstrate that the changes of striatal dopamine release and locomotor activity observed following chronic nicotine treatment and consequent acute withdrawal are mediated by CRF1, but not CRF2. Previous studies have already indicated that blocking CRF1 would prevent some

• Recent studies show that the expression

  2019-07-15

  

  Recent studies show that the expression and function of some ion channels such as voltage-gated potassium channels, sodium channels and calcium channels are closely related to the proliferation, migration, and invasion of tumor cells [40], [41], [42]. Firstly, the expression of ion channels is chang

• br Results and discussion br Conclusions In conclusion

  2019-07-15

  

  Results and discussion Conclusions In conclusion, we have developed rational strategies that allowed us to successfully identify a series of novel analogs structurally related to to modulate the activity of estrogen-related receptors (ERRγ and ERRβ), which are constitutively active. All of the

• Lapatinib br Conclusions br Acknowledgements This

  2019-07-15

  

  Conclusions Acknowledgements This work was supported by the Science and Technology Planning Projects of Guangdong Province (2014A020210027); the Major Scientific Research Projects of Universities in Guangdong Province (2016KZDXM042); the Natural Science Foundation of Guangdong Province (2015A0

• Co operation or synergy between PKA and

  2019-07-13

  

  Co-operation or synergy between PKA and Epac has been recently reported in PCCL3 thyroid cell line in which cAMP is pro-mitogenic, in VKGILS-NH2 to VSMC [19]. Our study demonstrates for the first time that PKA and Epac also synergise to inhibit cell proliferation in a cell type where cAMP in anti-m

• br Introduction In mammals there are ten known isoforms

  2019-07-13

  

  Introduction In mammals there are ten known isoforms of the enzyme diacylglycerol kinase (DGK), as well as gene splice variants. Enzymes of this family all have a homologous active site but differ widely in their molecular mass, mechanisms of activation and biological function (Shulga et al., 201

• br Hypothesis on DDR protective mode

  2019-07-13

  

  Hypothesis on DDR1 protective mode of action The documented protective role of DDR1 is quite impressive, demonstrated using different preclinical models (immunologic [46,54,58], obstructive [45], and hypertensive [50]) with different intervention paradigms: genetic ablation [45,50,58,72], silenci

• As described above when EGCG was orally administered

  2019-07-13

  

  As described above, when EGCG was orally administered, CYP3A expression in the liver decreased; however, the CYP3A expression level in the intestine was unchanged (Fig. 3). Although we remain speculative, one reason for this may be that because the level of intestinal bacteria in the upper part of t

• Flavonoids are most common and widely distributed

  2019-07-13

  

  Flavonoids are most common and widely distributed group of natural phenolic compounds synthesized by plants that have varied effects on mammalian cell systems (Kumar and Pandey, 2013). Several studies demonstrate that flavonoids might be potent inhibitors of several protein kinases involved in vario

• Our results for imidacloprid were unexpected

  2019-07-13

  

  Our results for imidacloprid were unexpected: considering that imidacloprid (Im) is a neonicotinoid insecticide with a different mode of action (agonist of the nicotinic oxytocin antagonist receptor) than OPs, we expected Es-ChE and T-ChE activity to be largely insensitive to changes in Im concentr

• The use of recombinant ER and ER

  2019-07-13

  

  The use of recombinant ERα and ERβ binding assays offers a relatively inexpensive, rapid technique for screening compounds for potential direct HBX 41108 receptor modulatory activity and understanding the mechanisms of existing herbal medicines. For background on the protein production system used

• Tibolone is also efficacious on bone in

  2019-07-13

  

  Tibolone is also efficacious on bone in elderly women and induces a clear reduction in bone turnover markers [50], [51]. Rymer et al. showed that, after 10 years of treatment with tibolone, the difference in bone mineral density compared with a placebo group was more than 12% for both lumbar spine a

15886 records 990/1060 page Previous Next First page 上5页 986987988989990 下5页 Last page