• Our study showed that parental morphine exposure

  2021-03-22

  

  Our study showed that parental morphine exposure in the adulthood is associated with an increased tendency toward morphine consumption in F1 but not F2 male offspring. Thus, it seems that trans-generational effects of parental morphine consumption disappear in the second generation. In support of ou

• br Methods for assessing TLS While the

  2021-03-22

  

  Methods for assessing TLS While the precise quantification of restricted DNA synthesis events is possible (e.g. unscheduled DNA synthesis (UDS) reveals NER), so far, it is impossible to identify TLS stretches of only a few nucleotides within the background of bulk DNA replication of normal DNA. N

• DGK negatively regulated the extension of long axon

  2021-03-22

  

  DGKδ negatively regulated the extension of long axon/neurite (Fig. 4, Fig. 5, Fig. 6). The results strongly suggest that deficiency of DGKδ induces OCD-like behavior by enhancing axon/neurite outgrowth. DGKδ positively regulates growth factor signaling (Crotty et al., 2006). Therefore, DGKδ deficien

• High throughput screening HTS of the AstraZeneca compound co

  2021-03-22

  

  High throughput screening (HTS) of the AstraZeneca bruton's tyrosine kinase collection was conducted and identified oxadiazole amide () originating from a kinase directed screening library (although inactive against a panel of kinases). This compound had moderate potency as a DGAT-1 inhibitor (IC=

• Despite low respiratory rates in citrus fruit prolonged peri

  2021-03-22

  

  Despite low respiratory rates in citrus fruit, prolonged periods of storage may cause significant changes in the levels of organic acids (Echeverria and Valich, 1988). V-ATPase and V-PPase catalyze the electrogenic H+ translocation from the cytosol to the vacuolar lumen to generate an inside-acid p

• In the pleural exudates which reflect the

  2021-03-22

  

  In the pleural exudates, which reflect the in vivo conditions, the concentrations of CysLTs and PGE2 were quite similar. However, when cancer Pyrintegrin were cultured for 24 h, both analyses of cell culture medium and cell incubations with Ca2+ ionophore showed low levels of CysLTs. In contrast, th

• In vivo study showed that the CYP A activity was

  2021-03-22

  

  In vivo study showed that the CYP3A activity was increased, when morroniside (10, 30 and 90 mg/kg, i.g.) was daily for seven consecutive days. Further, RT-PCR analysis showed that the induction of mRNA Bradykinin acetate by morroniside (10, 30 and 90 mg/kg, i.g.) was 1.13-, 1.43- and 1.79-fold high

• Application of the CPH model

  2021-03-22

  

  Application of the CPH model relies on the assumption that the hazard ratio of two observations is constant over time [2]. This enables us to infer the rate of risk of the treatment. For example, in the study of patients with pulmonary arterial hypertension (PAH) [5], the hazard ratio of a group of

• Our results for imidacloprid were unexpected considering

  2021-03-22

  

  Our results for imidacloprid were unexpected: considering that imidacloprid (Im) is a neonicotinoid insecticide with a different mode of action (agonist of the nicotinic Direct Mouse Genotyping Kit receptor) than OPs, we expected Es-ChE and T-ChE activity to be largely insensitive to changes in Im c

• br Experimental Procedures br Acknowledgments br Bisphenol

  2021-03-22

  

  Experimental Procedures Acknowledgments Bisphenol A (BPA) has been recognized as one of the most potent endocrine disruptors, functioning even at very low doses. Although it is anticipated that sennoside mg receptor (ER) would mediate these effects of low-dose BPA, studies revealed that BPA

• The prospects of the use of this novel

  2021-03-19

  

  The prospects of the use of this novel approach for the selective local thermo-activation of enzymes include biomedical and biotechnological applications. As NPs could be engineered to gain access to Benzoquinonium dibromide through the endosomal compartment [47] or through non-endocytotic pathways

• TgTCEA from petals TgTCEA and TgTCEB from pollen grains TgTC

  2021-03-19

  

  TgTCEA from petals (TgTCEA1) and TgTCEB from pollen grains (TgTCEB1) were used throughout the study. The recombinant enzymes were expressed in , and purified as the His-tag-free forms as described previously., Enzyme reactions were performed at 4 mM substrates under the same conditions as described

• Mechanistically GW treatment modulated cytokine expression w

  2021-03-19

  

  Mechanistically, GW2580 treatment modulated cytokine expression within the kidney. We noted a decrease in the levels of TNF, MCP-1, IL-1β, IL-27, and GM-CSF in GW2580 treated mice. Decreased levels of these proinflammatory cytokines likely contributed to the attenuated proteinuria and improved renal

• tbtu According to these results the power GaN

  2021-03-19

  

  According to these results, the power GaN seems more robust than existing technologies (VDMOS, Superjunction, IGBT,) [5,10] and [11]. Comparing with the SiC technology, the previous works show a low SEE tolerance [[12], [13], [14]] and [15]. The SOA of power GaN devices can be equivalent to the IGBT

• sorafenib tosylate The nucleus accumbens is a critical locus

  2021-03-19

  

  The nucleus accumbens is a critical locus for ER/mGluR signaling in the context of addiction ER/mGluR signaling is regulated by caveolin proteins and palmitoylation Because of the vast implications of ER/mGluR association, it is important to understand what regulates their interaction. Such regu

15605 records 653/1041 page Previous Next First page 上5页 651652653654655 下5页 Last page