• br Significance Cellular heterogeneity for phenotypic featur

  2021-09-10

  

  Significance Cellular heterogeneity for phenotypic features is a key mechanism underlying disease progression and therapeutic resistance, yet its regulation is poorly understood at the molecular level. Our findings demonstrate that endocrine resistance is associated with higher transcriptomic het

• Newly identified evidence has put immune checkpoint inhibito

  2021-09-10

  

  Newly identified evidence has put immune checkpoint inhibitors into the spotlight. However, even though they have been reported to achieve optimistic outcomes [67], there is still a provocative question about their limitations [68]. The solid evidence above has provided us with translational values

• There were limitations to this study Specifically although

  2021-09-10

  

  There were limitations to this study. Specifically, although rigorously examined for accuracy, the NCDB and SEER databases still suffer from issues with data entry and completeness of the treatment record. Of note, although the data were collected on a modern cohort of patients treated from 2010 to

• br An approach for the key challenges facing

  2021-09-10

  

  An approach for the key challenges facing forensic science One of the key challenges for forensic science is to avoid being side-tracked by one of the louder narratives in the media that the big problem forensic science faces is ‘junk science’ and ‘rogue scientists’. These are clearly important i

• br Hepatitis C virus HCV infection is

  2021-09-10

  

  Hepatitis C virus (HCV) infection is a major cause of chronic liver disease that can lead to cirrhosis and hepatocellular carcinoma. It is estimated that nearly 200 million individuals worldwide are currently infected with HCV and it is the leading cause of liver transplants. The current standard

• br Material and methods br

  2021-09-10

  

  Material and methods Results Discussion In vitro testing is necessary to study DAA activity and putative RASs. Compared to enzymatic assays and replicons, HCV infectious culture systems reflect the full viral life cycle and previous results in these systems reflected clinical data.[13], [14

• It was reported that GPR is expressed

  2021-09-10

  

  It was reported that GPR120 is expressed on macrophages in adipose tissue (Oh et al., 2010). Whether GPR120-positive Heparin in human and rat pancreas belongs to macrophages was studied. CD68 is a transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages (Horikaw

• br Conclusion br Conflict of interest statement br Reference

  2021-09-10

  

  Conclusion Conflict of interest statement References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as Introduction Over the past decade, more than a hundred new biopharmaceutical products have been approved and market

• br Recent insights into EAAT structure

  2021-09-09

  

  Recent insights into EAAT structure/function aspects The EAATs are secondary-active transporters coupling the movement of one Glu with the symport of three Na+ and one proton and the counter-transport of one K+ [3, 4]. The transporters are trimeric assemblies of protomers that function independen

• To evaluate SLC A abundance after transfection

  2021-09-09

  

  To evaluate SLC45A1 abundance after transfection, we performed western blots. Transfected COS-7 TNF-alpha, recombinant human protein receptor were lysed and separated for membrane fraction. Equal amounts of proteins from membrane fractions were resolved by SDS-PAGE, transferred to a nitrocellulose

• Consistent with recent independent studies we

  2021-09-09

  

  Consistent with recent independent studies, we confirm that the GCG-induced increase in oxygen consumption is only partially blunted in Fgf21−/− mice [32], implicating additional GCGR-dependent mechanisms contributing to the acute GCG-dependent enhancement of energy expenditure. Notably, glucagon ad

• Analgesic activity was evaluated by measuring tail flick lat

  2021-09-09

  

  Analgesic activity was evaluated by measuring tail flick latencies to the immersion of rat’s tail in water, maintained at ∼51°C [18] after recovery from anesthesia. Typically, rats were immobilized inside a restrainer, leaving only the tail exposed, which was then immersed into the hot water bath, a

• br Material and methods br Results br Discussion

  2021-09-09

  

  Material and methods Results Discussion Propofol is commonly used in operation rooms or intensive care units (ICUs) for critically ill patients. Various clinical trials have demonstrated that the antioxidant, anti-inflammatory, and free-radical-scavenging properties of propofol can provide

• Ning et al showed that LPC appeared

  2021-09-09

  

  Ning et al. showed that LPC 18:1 appeared to increase insulin release through both GPR119-dependent and -independent mechanisms (Ning et al., 2008). In our study, we have shown that not only GPR119 but also GPR40 and GPR55 participate in LPC-stimulated insulin secretion (Fig. 4, Fig. 5) and target p

• br Conclusion br Acknowledgements This work was supported by

  2021-09-09

  

  Conclusion Acknowledgements This work was supported by R01 HL127386 (Niklason) and 1R01 HL128406-01A1 (Dardik), and by an unrestricted research gift from Humacyte Inc. KLL was supported by F30HL143880. KLL and EQ were supported by T32 GM007205. LEN is a founder and shareholder in Humacyte, Inc

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