• The activation of Notch has

  2018-10-24

  

  The activation of Notch1 has been found to contribute to the invasion and metastasis of cancer via the EMT. In addition, Saad et al. (2010) showed that the overexpression of NOTCH1 induces the expression of SNAIL. In the present study, after GSI treatment the expression of NOTCH1, SNAIL1, and SNAIL2

• We speculated that MEKi might decrease DNA methylation

  2018-10-24

  

  We speculated that MEKi might decrease DNA methylation levels through the downregulation of the DNMT3 family. MEKi significantly diminished global DNA methylation levels and, surprisingly, was sufficient to induce high 5hmC levels. Because the TET family of dioxygenases that catalyze the conversion

• br This result is not

  2018-10-24

  

  This result is not unexpected, as the Crocco Eq. (3) is equivalent to a canonical system. A similar result is obtained when splitting series in the case of the Blasius equation: which is not connected to any variational problems. Furthermore, let y be and the split linear system takes the for

• br Numerical computations We present here the calculation da

  2018-10-24

  

  Numerical computations We present here the calculation data obtained for the structure prepared from ytterbium (Yb, eφ = 3.1 eV) and carbon (C, eφ = 4.7 eV) layers. Calculations necessary to optimize the layered field emitters and determine their emission characteristics have been carried out us

• Fiber separation in the reinforcing yarns and damages in

  2018-10-24

  

  Fiber separation in the reinforcing yarns and damages in the yarn matrix may occur during the deformation of flexible woven composite materials due to debonding between the reinforcing fibers and the adhesive. These processes can be described as \'smeared cracks’ [18-21]. This description is based o

• whose general solution has the form br

  2018-10-24

  

  whose general solution has the form Let us consider a rectangular plate with the relative dimensions where γ=a/b is the aspect ratio of the plate. If we impose the requirement that deflection function (2) of the plate must satisfy the homogenous boundary conditions at the edges y=0 and y=1, the

• The full spin of the

  2018-10-24

  

  The full spin of the Fe2+ ion can be equal to 4/2 or 0 depending on whether external molecular complex is adjoined to it. Let us note that this property determines the possibility of the oxygen transport by the red blood ap-1 in living organisms. It is shown in this paper that, in the case of sill

• Literacy is a fundamental resource highly correlated with

  2018-10-24

  

  Literacy is a fundamental resource highly correlated with educational attainment. Broadly, literacy has been defined as using printed and written information to function in society, to achieve one’s goals, and to develop one’s knowledge and potential. Literacy enables individuals to gain knowledge a

• The use of good quality instruments is necessary when

  2018-10-24

  

  The use of good quality instruments is necessary when examining associations between adolescents’ neighbourhood social environments and their health and well-being. Different approaches are taken to conceptualisation, operationalisation and measurement which might explain inconsistent research findi

• The levels of healthcare spending

  2018-10-24

  

  The levels of healthcare spending by states and the US are a result of specific policy choices (Zimmerman, 2013). They reflect decisions not to negotiate over the price of pharmaceuticals, to avoid price transparency, and to prohibit the use of cost-effectiveness analyses in health priority setting.

• Brazilian increasing trade deficit in industrial sectors is

  2018-10-23

  

  Brazilian increasing trade deficit in industrial sectors is driven by many factors, some related to macroeconomic policies, such as exchange rates, and other are structural. According to World Bank (2008), a country\'s technology purchase Monastrol depends on skilled workforce, investment climate t

• Within the set of personal explicative variables the highest

  2018-10-23

  

  Within the set of personal explicative variables, the highest impact on the probability ratio of being happier in relation to being less happy is explained by the “married” marital status. This likelihood is 1.6 times higher for married people than for those who remain unmarried. Di Tella et al. (20

• Interestingly in their simulation model Lodding and colleagu

  2018-10-23

  

  Interestingly, in their simulation model, Lodding and colleagues were able to predict their real rate of recipients with a high CMV viral load (1.4%, arbitrarily set at >18,200IU/mL) with the assumption of their lower doubling time of 4.3days. Using a shorter doubling time of 1.3days, the proportion

• There was no evidence of publication bias across

  2018-10-23

  

  There was no evidence of publication bias across studies that reported on alcohol-dependent subjects vs the general population, alcohol-dependent subjects vs subjects qualifying for a diagnosis of alcohol abuse, or alcohol-dependent subjects with continued heavy drinking vs alcohol-dependent subject

• The cytological library we have developed

  2018-10-23

  

  The cytological library we have developed provides a versatile reference data set for the analysis of S. aureus strains that can be expanded to include new data from reference strains as well as new strains as they evolve. Indeed, realizing the clinical potential of BCP as an antimicrobial susceptib

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