• br Conclusions Additional research is needed using

  2018-11-05

  

  Conclusions Additional research is needed using larger sample sizes to conduct mediation analyses and including preclinical data to confirm that the increased lung cancer risk of associated SNPs is causally driven entirely by increased smoking intensity. However, our results add to the growing li

• The method used in our study for

  2018-11-05

  

  The method used in our study for measuring epigenetic age was based on a model trained on genome-wide DNA methylation extracted from WBC (Hannum et al., 2013). As our measurements were taken from extracted WBC, epigenetic age measured in our study could be a proxy measure for the immune response to

• To show seasonality of VC over a

  2018-11-05

  

  To show seasonality of VC over a year, decade averages of VC for each month was displayed as a function of the month in a year. For the recent decade, 13 cities were chosen to compare seasonality of DEP. Ten European cities were selected to represent most of the European continent with different tem

• Certainly the jury is still out

  2018-11-05

  

  Certainly the jury is still out on the best way to deliver OVs and arguments can be made for either loco-regional or systemic administration. Indeed the flexibility around delivering OVs by different routes, depending on the clinical setting, may be an advantage over more traditional therapeutic mod

• Even though it has been suggested that

  2018-11-05

  

  Even though it has been suggested that the glial scar has inhibitory effects on self-repair and neuroregeneration after SCI, recent studies showed that astrocytes, ependymal and inflammatory purchase CA 074 have also pro-regenerative properties (Anderson et al., 2016; Barnabe-Heider et al., 2010; R

• In Brazil the Pereskia aculeata Miller plant is popularly kn

  2018-11-05

  

  In Brazil, the Pereskia aculeata Miller plant is popularly known as ora-pro-nóbis (OPN). It belongs to the cactaceae family and is used as a nutritional supplement due to its protein, fiber, iron and calcium content. This non-conventional vegetable has succulent leaves, is edible, and can be used in

• br Introduction Wet scrubbers are important air pollution

  2018-11-05

  

  Introduction Wet scrubbers are important air pollution control devices for cleaning large volumes of industrial effluent gas streams and they remove particulates and dangerous gases simultaneously by capturing into the droplets or pool of liquid and dissolving or absorbing into the liquid respect

• The diagnosis of OSAS is one of the

  2018-11-05

  

  The diagnosis of OSAS is one of the key problems in this field. Although polysomnography is considered as the gold standard for the diagnosis of OSAS [1], this method is not yet widely available due, probably, to its high cost. Thus, some attempts have been made to develop self-report measures based

• Sleep deprivation seems to be

  2018-11-05

  

  Sleep deprivation seems to be related to the elevation of cortisol, reflecting impairment of HPA axis regulation, and resulting in glucocorticoid overload, which can lead to large deleterious effects on the body. Moreover, there is an association between short sleep duration and higher risk of devel

• br Introduction Printing of enzymes

  2018-11-05

  

  Introduction Printing of Erlotinib on paper or cardboard can add valuable functionalities to the substrate. These functionalized paper-based products could be used in low-cost diagnostics [24,53], indicators [7,9,41] or bioelectronics. In bioelectronics the functionality of the device is typical

• aims to be a truly global forum for high quality

  2018-11-05

  

  aims to be a truly global forum for high‐quality sexual medicine research; we advocate that the best research should be published and made widely accessible as quickly as possible. As a journal with global aspirations, \'s editorial board was selected to reflect the diversity of our society and memb

• Dysregulation or mutations of catenin are widespread in

  2018-11-03

  

  Dysregulation or mutations of β-catenin are widespread in GIC, and altered β-catenin plays fundamental roles in GIC initiation and progression (Basu et al., 2016; Oguma et al., 2008; Vogelstein et al., 2013). By interacting with β-catenin, ASF1A thus exhibits multiple oncogenic activities, as docume

• br Bioinformatic analyses Standard bioinformatics analyses a

  2018-11-03

  

  Bioinformatic analyses Standard bioinformatics analyses about this work were reported by Yang et al. [1]. We calculated gene expression values by the read/fragments per kilobase of consistency per million fragments mapped (RPKM/FPKM) and the False Discovery Rate (FDR). Genes with an FPKM ratio ≥2

• Brain imaging and genetic data alone

  2018-11-03

  

  Brain imaging (and genetic) data alone are insufficient for tracking trajectories in small molecule library screening development. A significant time commitment must be made to the assessment of cognition and mental health. In the Saguenay Youth Study, for example, we have spent ∼8 h of the partici

• br Methods br Results br Discussion br Conclusion br

  2018-11-03

  

  Methods Results Discussion Conclusion Conflicts of interest Acknowledgements Introduction Cross-sectional and longitudinal structural magnetic resonance imaging (MRI) studies have demonstrated that the human brain undergoes significant development during adolescence (Gogtay et a

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