• br An estimated million babies are born

  2019-05-13

  

  An estimated 15 million babies are born preterm annually. Preterm birth complications account for more than 15% of deaths in children younger than 5 years and survivors often have long-term consequences with respect to their health, growth, and psychosocial functioning. The most beneficial interve

• Paraguay es puntual en la redacci n

  2019-05-13

  

  Paraguay es puntual en la redacción del Artículo 8 de su Constitución Nacional cuando dice que “Las actividades susceptibles de producir alteración ambiental serán reguladas por la ley. Asimismo, ésta podrá restringir o prohibir aquéllas que califique peligrosas”. Describe allí las actividades que p

• Introduction By catalyzing post translational acetylation of

  2019-05-13

  

  Introduction By catalyzing post-translational acetylation of lysine residues, the histone acetyl transferases (HAT) CREBBP and EP300 moderate the activities of both histone and non-histone proteins. This regulates vital cellular processes such as cell cycling and apoptosis by modulating chromatin s

• br Materials and methods br Results

  2019-05-13

  

  Materials and methods Results and discussion ABT-737 is a BH3-mimetic targeting Bcl-2, Bcl-XL and Bcl-W. The aim of the experiments was to test whether inhibition of Bcl-2 and Bcl-XL using ABT-737 can eradicate the CD34+/CD38− AML cell population. Bone marrow MNCs from patients (Table 1) were

• br Conclusion br Authors contribution br Competing interests

  2019-05-13

  

  Conclusion Authors’ contribution Competing interests Acknowledgments Case report Imatinib has radically changed prognosis in chronic-phase Chronic Myeloid Leukemia (CML), with 90% overall survival rate at 8yrs, and 40–70% of patients achieving a stable MMR [1]. Even better results hav

• There was a modest excess risk of mortality

  2019-05-13

  

  There was a modest excess risk of mortality associated with multidrug-resistant organisms, which was lower than that previously recorded in south Asia. There are methodological challenges in the attribution of excess neonatal mortality with antimicrobial resistance because of known confounding with

• Therefore if appropriate vitamin supplement times wk for

  2019-05-13

  

  Therefore, if appropriate vitamin supplement (>3 times/wk) for pregnant women would reduce the serum levels of copper, which has been demonstrated in the current issue of the , is it possible that the fetus might escape a potentially toxic bioaccumulation of mercury and copper? Of course, the fetus

• Introduction Brugada syndrome is severe arrhythmia character

  2019-05-13

  

  Introduction Brugada syndrome is severe arrhythmia characterized by specific ST elevations in precordial leads and sudden ventricular fibrillation (VF), and the condition may result in sudden cardiac death [1–5]. By implanting defibrillation devices, also known as implantable cardioverter-defibrill

• br The L type calcium channel LTCC in heart consists

  2019-05-10

  

  The L-type calcium channel (LTCC) in heart consists of 4 subunits: α1, β2, α2, and δ [47], encoded by CACNA1C, CACNB2, and CACNA2D, respectively, with the α2 and δ subunits encoded by the gene CANA2D. In 2007, Antzelevitch et al. [48] reported 2 CACNA1C mutations and a CACNB2 mutation from a genot

• br Discussion Furthermore most of

  2019-05-10

  

  Discussion Furthermore most of the previously described cases with a solitary lesion affecting bone involved the craniofacial bones [2–7], and only a few cases affected the appendicular skeleton. Several affected extra-craniofacial sites have been sporadically reported, for example: femur [8], ti

• The exact incidences of amiodarone induced

  2019-05-10

  

  The exact incidences of amiodarone-induced hyperthyroidism and amiodarone-induced hypothyroidism currently remain unknown; however, the reported frequencies of amiodarone-induced hyperthyroidism and amiodarone-induced hypothyroidism vary widely from 0.8% to 37.8% [7–16] and from 1% to 32% [13,17–20]

• The Cl HCO anion exchanger AE is found on cholangiocytes

  2019-05-10

  

  The Cl−/HCO3− anion exchanger 2 (AE2) is found on cholangiocytes and regulates intracellular pH homeostasis and stimulates bicarbonate secretion. Previous reports have revealed that PBC patients show decreased biliary AE2 expression, and researchers hypothesized that this decrease in AE2 GSK-3 Inhib

• br ALANISMO E IZQUIERDA UNIDA

  2019-05-10

  

  ALANISMO E IZQUIERDA UNIDA No plano político, o desmoronamento da iu está associado às ambiguidades com que se relacionou com a primeira força política do país neste momento, o apra e o presidente Alan García. Especificamente, o grupo em torno de Alfredo Barrantes acreditou em um cenário de alter

• FPET is a valuable tool to support

  2019-05-10

  

  FPET is a valuable tool to support monitoring of SDG 3·7, which calls for universal access to family planning by 2030, albeit with a focus on demand and utilisation rather than access. Nonetheless, subnational geographic projections must be considered in light of some data limitations. Unmarried wom

• opioid receptor Pharmacological inhibition of PI K induces a

  2019-05-10

  

  Pharmacological inhibition of PI3Kα induces apoptosis of CLL opioid receptor in vitro [5,18], and inhibits CLL migration towards CXCL12 [5]. The PI3Kα/δ inhibitor copanlisib induces significantly greater apoptosis of CLL cells compared to idelalisib (IC50 of 450nM and >10μM, respectively) in vitro a

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