• To investigate this potentially increased

  2018-10-30

  

  To investigate this potentially increased proportion of patients with rapid progression to AIDS over the last decade in Cuba, we set up an exploratory study evaluating the association of rapid progression with epidemiological, clinical, viral and immunological parameters, comparing three groups of p

• Glial cells are likely implicated in the physiopathology

  2018-10-30

  

  Glial cells are likely implicated in the physiopathology of depression. Post-mortem studies have shown a decreased density of glial cells in the prefrontal cortex and the hippocampus of depressed patients (Cotter et al., 2001; Ongur et al., 1998). Accordingly, preclinical studies demonstrated that a

• Exploring the human host response to TB provides opportunity

  2018-10-30

  

  Exploring the human host response to TB provides opportunity for the discovery of biomarkers, and the development of additional diagnostics that do not require samples from the site of disease and that are not based on the detection of Mtb. Mass spectrometry (MS) allows rapid quantitative assessment

• Previous studies of functional connectivity in autism have

  2018-10-30

  

  Previous studies of functional connectivity in autism have examined either task-related or resting-state connectivity, with mixed findings of over- and under-compared with neurotypical populations (see for reviews). Very few have examined differential brain connectivity as a function of brain state,

• In summary Scholz et al have tackled a critical

  2018-10-30

  

  In summary, Scholz et al. have tackled a critical issue in biomedicine relating to human CD4 and CD8 T memory stem cell generation and function. Although the molecular mechanism(s) of T cell generation remain nebulous vis-à-vis the relative role of WNT/β-catenin or mTOR modulation, the current repor

• From studies with mouse models Huber Lang et al Hoth

  2018-10-30

  

  From studies with mouse models (Huber-Lang et al., 2006; Hoth et al., 2014; Khan et al., 2013; Auger et al., 2012; Zecher et al., 2014; Borkowska et al., 2014), several groups have concluded that thrombin is the major coagulation enzyme that generates C5a under pathologic conditions. This role for t

• A cursory examination of its

  2018-10-30

  

  A cursory examination of its assumptions raises some immediate questions. Pregnant women in the third trimester are not very comparable to “adults” in the physiology of resuscitation: their dihydrofolate reductase inhibitor is higher and chest compressions are less effective. Hence, the four-minute

• br Introduction Prostate cancer strikes one

  2018-10-30

  

  Introduction Prostate cancer strikes one in six men and is the second leading cause of cancer-related deaths in men after lung cancer in the United States. Prostate cancer arises mainly from prostatic intraepithelial neoplasia (PIN), a precursor lesion that ultimately progresses to adenocarcinoma

• The following are the supplementary

  2018-10-30

  

  The following are the supplementary data related to this article. Potential conflicts of interest Author contributions Acknowledgements This work was supported by the Defense Advanced Research Projects Agency (DARPA) grant N66001-11-1-4180 and the Wyss Institute for Biologically Inspired E

• Human lung tissue from eight donors without

  2018-10-30

  

  Human lung tissue from eight donors “without overt disease, but unsuitable for transplant” was provide by the Life Alliance Organ Recovery Agency. cDNA was obtained from human lung parenchyma and used to amplify regions of CACNA1C known to present splicing variation. Eight splice variant combination

• br RNA interference RNAi and ectopic expression To address

  2018-10-29

  

  RNA interference (RNAi) and ectopic expression To address the functionalities of the identified proteins, we silenced the coding genes of these proteins in a normal colonic fibroblast cell line, CCD-18Co, and then performed coculture assays with colon cancer cells. Follistatin-related protein 1 (

• bet inhibitor br Acknowledgements This research is supported

  2018-10-29

  

  Acknowledgements This research is supported by Health Canada. Specifications table Value of the data Data, materials and methods Acknowledgments Specifications table Value of the data Data and experimental design Fibroblasts are the most abundant cell type in connective tissues,

• br Specification table br Value of the data br Data

  2018-10-29

  

  Specification table Value of the data Data Data on comparative antimycobacterial activity of total hydroethanolic extracts derived from five medicinal plant species is presented (Table 1). Data on in vitro cytotoxic activity of tested plant species and positive control drugs, isoniazid, rif

• br Experimental design materials and

  2018-10-29

  

  Experimental design, materials and methods Acknowledgments This work was supported by Colon Cancer Canada and support for Dr. V. Ho (postdoctoral fellow) was provided by the Canadian Institutes of Health Research Postdoctoral Fellowship. Data These data were collected as described in detai

• br Data Dataset provided in this article shows the NMR

  2018-10-29

  

  Data Dataset provided in this article shows the NMR spectra for compounds extracted from native Australian plants species Pilidiostigma glabrum, Myoporum montanum, Geijera parviflora, and Rhodomyrtus psidioides. In addition to collagen synthesis [5], additional analysis was performed to determine

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